Ethambutol changes the color coding of carp retinal ganglion cells reversibly.
نویسندگان
چکیده
The influence of ethambutol on retinal function was studied by recording ganglion cell responses in isolated carp retinas superfused with a Ringer solution containing different concentrations of ethambutol (0 mg/liter, 10 mg/liter, 20 mg/liter, 30 mg/liter). The results indicate that ethambutol reversibly affects color opponency, without changing the sensitivity of the underlying receptor processes. The amacrine and bipolar cells are the most likely candidates to be affected by ethambutol.
منابع مشابه
Retinal Ganglion Cell Complex in Alzheimer Disease: Comparing Ganglion Cell Complex and Central Macular Thickness in Alzheimer Disease and Healthy Subjects Using Spectral Domain-Optical Coherence Tomography
Introduction: Alzheimer disease (AD) is the most common form of dementia worldwide. The modalities to diagnose AD are generally expensive and limited. Both the central nervous system (CNS) and the retina are derived from the cranial neural crest; therefore, changes in retinal layers may reflect changes in the CNS tissue. Optical coherence tomography (OCT) machine can show delicate retinal layer...
متن کاملLateral feedback from monophasic horizontal cells to cones in carp retina. II. A quantitative model
About half of the monophasic horizontal cells in carp retina receive input from both red- and green-sensitive cones. Since the horizontal cells feed back to cones, the color and feedback pathways result in wavelength- and intensity-dependent changes of the dynamics and of the receptive field amplitude profile of the horizontal cell responses. In this paper we present a quantitative model that d...
متن کاملStem Cells in Glaucoma Management
Glaucoma is the leading cause of preventable blindness worldwide. Despite tremendous advances in medical and surgical management of glaucoma in the recent years, the prevalence of glaucoma related blindness is anticipated to increase in the future decades because of the aging population. Stem cells have the potential to change the glaucoma management in several ways. There are several areas of ...
متن کاملChloride channel protein 2 prevents glutamate-induced apoptosis in retinal ganglion cells
Objective(s): The purpose of this study was to investigate the role of chloride channel protein 2 (ClC-2) in glutamate-induced apoptosis in the retinal ganglion cell line (RGC-5). Materials and Methods: RGC-5 cells were treated with 1 mM glutamate for 24 hr. The expression of ClC-2, Bax, and Bcl-2 was detected by western blot analysis. Cell survival and apoptosis were measured by 3-(4,5-dimeth...
متن کاملChromatic Coding from Cone-type Unselective Circuits in the Mouse Retina
Retinal specializations such as cone-photoreceptor opsin-expression gradients, as found in several vertebrate species, are intuitively considered detrimental to color vision. In mice, the majority of cones coexpress both "blue" and "green" opsin. The coexpression ratio changes along the dorsoventral axis, resulting in a "green"-dominant dorsal and a "blue"-dominant ventral retina. Here, we aske...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Investigative ophthalmology & visual science
دوره 24 1 شماره
صفحات -
تاریخ انتشار 1983